Comprehensive IBSI Benchmark Results

How to Run the Benchmarks

To reproduce these results or run the IBSI compliance benchmarks on your own system:

1. Download the Data

The IBSI reference datasets (Digital Phantom and Lung Cancer CT) are available on the IBSI GitHub repository.

Digital Phantom: Download phantom.nii.gz and mask.nii.gz from the digital_phantom folder.
Lung Cancer CT: Download the PAT1 NIfTI files. Note that IBSI recommends converting these to at least 32-bit floating point and rounding to the nearest integer before processing.

Place these files in dev/IBSI1/data/ or provide their paths to the script.

2. Run Configurations Programmatically using `RadiomicsPipeline`

You can run any of the IBSI configurations programmatically using the RadiomicsPipeline class.

from pictologics.pipeline import RadiomicsPipeline
from pictologics.loader import load_image

# 1. Initialize Pipeline
pipeline = RadiomicsPipeline()

# --- DEFINE CONFIGURATIONS ---

# A. Digital Phantom Config (FBS 1.0, no resampling)
config_digital_phantom = [
    {"step": "discretise", "params": {"method": "FBS", "bin_width": 1.0}},
    {"step": "extract_features", "params": {"families": ["intensity", "morphology", "texture", "histogram", "ivh"], "include_spatial_intensity": True, "include_local_intensity": True}}
]

# B. Config C (2mm isotropic, resegment [-1000, 400], FBS 25 HU)
config_c = [
    {"step": "binarize_mask", "params": {"threshold": 0.5}},
    {"step": "resample", "params": {"new_spacing": (2.0, 2.0, 2.0), "interpolation": "linear", "round_intensities": True}},
    {"step": "keep_largest_component", "params": {"apply_to": "morph"}},
    {"step": "resegment", "params": {"range_min": -1000, "range_max": 400}},
    {"step": "discretise", "params": {"method": "FBS", "bin_width": 25.0, "min_val": -1000}},
    {"step": "extract_features", "params": {"families": ["intensity", "morphology", "texture", "histogram", "ivh"], "include_spatial_intensity": True, "include_local_intensity": True, "ivh_discretisation": {"method": "FBS", "bin_width": 2.5, "min_val": -1000}, "ivh_params": {"target_range_max": 400}}}
]

# C. Config D (2mm isotropic, 3-sigma outlier, FBN 32, Continuous IVH)
config_d = [
    {"step": "binarize_mask", "params": {"threshold": 0.5}},
    {"step": "resample", "params": {"new_spacing": (2.0, 2.0, 2.0), "interpolation": "linear", "round_intensities": True}},
    {"step": "keep_largest_component", "params": {"apply_to": "morph"}},
    {"step": "filter_outliers", "params": {"sigma": 3.0}},
    {"step": "discretise", "params": {"method": "FBN", "n_bins": 32}},
    {"step": "extract_features", "params": {"families": ["intensity", "morphology", "texture", "histogram", "ivh"], "include_spatial_intensity": True, "include_local_intensity": True, "ivh_use_continuous": True}}
]

# D. Config E (Cubic resamp, 3-sigma, round last, FBN 32 for tex, FBN 1000 for IVH)
config_e = [
    {"step": "binarize_mask", "params": {"threshold": 0.5}},
    {"step": "resample", "params": {"new_spacing": (2.0, 2.0, 2.0), "interpolation": "cubic", "round_intensities": False}},
    {"step": "keep_largest_component", "params": {"apply_to": "morph"}},
    {"step": "resegment", "params": {"range_min": -1000, "range_max": 400}},
    {"step": "filter_outliers", "params": {"sigma": 3.0}},
    {"step": "round_intensities", "params": {}},
    {"step": "discretise", "params": {"method": "FBN", "n_bins": 32}},
    {"step": "extract_features", "params": {"families": ["intensity", "morphology", "texture", "histogram", "ivh"], "include_spatial_intensity": True, "include_local_intensity": True, "ivh_discretisation": {"method": "FBN", "n_bins": 1000}, "ivh_params": {"bin_width": 1.0, "min_val": 0.5, "max_val": 1000.5}}}
]

# --- RUN PIPELINE ---
# Choose which config to run:
pipeline.add_config("ibsi_config_c", config_c)

# 3. Load image and mask
# For Config C/D/E (Lung Cancer CT)
image = load_image("path/to/CT_image.nii.gz")
mask = load_image("path/to/CT_mask.nii.gz")

# 4. Run extraction
results = pipeline.run(image, "ibsi_config_c", mask=mask)

# 5. Access results
print(results["ibsi_config_c"])

Pictologics considers all data as 3D volumes (even 2D slices are converted to 3D volumes) and does not support 2D radiomic extraction mechanisms. Therefore, benchmark comparisons to configuration A and B are not possible.

Digital Phantom

Morphology

Feature	Code	Calc	Ref	Tol	Status
Volume	RNU0	556	556	4	✅ PASS
Volume voxel counting	YEKZ	592	592	4	✅ PASS
Surface area	C0JK	388	388	3	✅ PASS
Surface to volume ratio	2PR5	0.698	0.698	0.004	✅ PASS
Compactness 1	SKGS	0.0411	0.0411	0.0003	✅ PASS
Compactness 2	BQWJ	0.599	0.599	0.004	✅ PASS
Spherical disproportion	KRCK	1.19	1.19	0.01	✅ PASS
Sphericity	QCFX	0.843	0.843	0.005	✅ PASS
Asphericity	25C7	0.186	0.186	0.001	✅ PASS
Center of mass shift	KLMA	0.672	0.672	0.004	✅ PASS
Maximum 3D diameter	L0JK	13.1	13.1	0.1	✅ PASS
Major axis length	TDIC	11.4	11.4	0.1	✅ PASS
Minor axis length	P9VJ	9.31	9.31	0.06	✅ PASS
Least axis length	7J51	8.54	8.54	0.05	✅ PASS
Elongation	Q3CK	0.816	0.816	0.005	✅ PASS
Flatness	N17B	0.749	0.749	0.005	✅ PASS
Volume density (AABB)	PBX1	0.869	0.869	0.005	✅ PASS
Area density (AABB)	R59B	0.866	0.866	0.005	✅ PASS
Volume density (OMBB)	ZH1A	0.458	—	—	❗ REF.
Area density (OMBB)	IQYR	0.5673	—	—	❗ REF.
Volume density (AEE)	6BDE	1.17	1.17	0.01	✅ PASS
Area density (AEE)	RDD2	1.36	1.36	0.01	✅ PASS
Volume density (MVEE)	SWZ1	0.513	—	—	❗ REF.
Area density (MVEE)	BRI8	0.7909	—	—	❗ REF.
Volume density (convex hull)	R3ER	0.961	0.961	0.006	✅ PASS
Area density (convex hull)	7T7F	1.03	1.03	0.01	✅ PASS

Intensity

Feature	Code	Calc	Ref	Tol	Status
Integrated intensity	99N0	1195	1.2e3	10	✅ PASS
Moran's I index	N365	0.0397	0.0397	0.0003	✅ PASS
Geary's C measure	NPT7	0.974	0.974	0.006	✅ PASS
Local intensity peak	VJGA	2.6	2.6	—	✅ PASS
Global intensity peak	0F91	3.1	3.1	—	✅ PASS
Mean intensity	Q4LE	2.15	2.15	—	✅ PASS
Intensity variance	ECT3	3.05	3.05	—	✅ PASS
Intensity skewness	KE2A	1.08	1.08	—	✅ PASS
Intensity kurtosis	IPH6	-0.355	-0.355	—	✅ PASS
Median intensity	Y12H	1	1	—	✅ PASS
Minimum intensity	1GSF	1	1	—	✅ PASS
10th intensity percentile	QG58	1	1	—	✅ PASS
90th intensity percentile	8DWT	4	4	—	✅ PASS
Maximum intensity	84IY	6	6	—	✅ PASS
Intensity interquartile range	SALO	3	3	—	✅ PASS
Intensity range	2OJQ	5	5	—	✅ PASS
Intensity Mean absolute deviation	4FUA	1.55	1.55	—	✅ PASS
Intensity Robust mean absolute deviation	1128	1.11	1.11	—	✅ PASS
Intensity Median absolute deviation	N72L	1.15	1.15	—	✅ PASS
Intensity Coefficient of variation	7TET	0.812	0.812	—	✅ PASS
Intensity Quartile coefficient of dispersion	9S40	0.6	0.6	—	✅ PASS
Intensity energy	N8CA	567	567	—	✅ PASS
Root mean square intensity	5ZWQ	2.77	2.77	—	✅ PASS

Intensity Histogram

Feature	Code	Calc	Ref	Tol	Status
Mean discretised intensity	X6K6	2.15	2.15	—	✅ PASS
Discretised intensity variance	CH89	3.05	3.05	—	✅ PASS
Discretised intensity skewness	88K1	1.08	1.08	—	✅ PASS
Discretised intensity kurtosis	C3I7	-0.355	-0.355	—	✅ PASS
Median discretised intensity	WIFQ	1	1	—	✅ PASS
Minimum discretised intensity	1PR8	1	1	—	✅ PASS
10th discretised intensity percentile	1PR	1	1	—	✅ PASS
90th discretised intensity percentile	GPMT	4	4	—	✅ PASS
Maximum discretised intensity	3NCY	6	6	—	✅ PASS
Intensity histogram mode	AMMC	1	1	—	✅ PASS
Discretised intensity interquartile range	WR0O	3	3	—	✅ PASS
Discretised intensity range	5Z3W	5	5	—	✅ PASS
Intensity histogram mean absolute deviation	D2ZX	1.55	1.55	—	✅ PASS
Intensity histogram robust mean absolute deviation	WRZB	1.11	1.11	—	✅ PASS
Intensity histogram median absolute deviation	4RNL	1.15	1.15	—	✅ PASS
Intensity histogram coefficient of variation	CWYJ	0.812	0.812	—	✅ PASS
Intensity histogram quartile coefficient of dispersion	SLWD	0.6	0.6	—	✅ PASS
Discretised intensity entropy	TLU2	1.27	1.27	—	✅ PASS
Discretised intensity uniformity	BJ5W	0.512	0.512	—	✅ PASS
Maximum histogram gradient	12CE	8	8	—	✅ PASS
Maximum histogram gradient intensity	8E6O	3	3	—	✅ PASS
Minimum histogram gradient	VQB3	-50	-50	—	✅ PASS
Minimum histogram gradient intensity	RHQZ	1	1	—	✅ PASS

Intensity-Volume Histogram

Feature	Code	Calc	Ref	Tol	Status
Volume at intensity fraction 0.10	BC2M_10	0.324	0.324	—	✅ PASS
Volume at intensity fraction 0.90	BC2M_90	0.0946	0.0946	—	✅ PASS
Intensity at volume fraction 0.10	GBPN_10	5	5	—	✅ PASS
Intensity at volume fraction 0.90	GBPN_90	2	2	—	✅ PASS
Volume fraction difference between intensity 0.10 and 0.90 fractions	DDTU	0.23	0.23	—	✅ PASS
Intensity fraction difference between volume 0.10 and 0.90 fractions	CNV2	3	3	—	✅ PASS
Area under the IVH curve	9CMM	2.047	—	—	❗ REF.

GLCM

Feature	Code	Calc	Ref	Tol	Status
Joint maximum	GYBY	0.509	0.509	—	✅ PASS
Joint average	60VM	2.15	2.15	—	✅ PASS
Joint variance	UR99	3.13	3.13	—	✅ PASS
Joint entropy	TU9B	2.57	2.57	—	✅ PASS
Difference average	TF7R	1.38	1.38	—	✅ PASS
Difference variance	D3YU	3.21	3.21	—	✅ PASS
Difference entropy	NTRS	1.64	1.64	—	✅ PASS
Sum average	ZGXS	4.3	4.3	—	✅ PASS
Sum variance	OEEB	7.41	7.41	—	✅ PASS
Sum entropy	P6QZ	2.11	2.11	—	✅ PASS
Angular second moment	8ZQL	0.291	0.291	—	✅ PASS
Contrast	ACUI	5.12	5.12	—	✅ PASS
Dissimilarity	8S9J	1.38	1.38	—	✅ PASS
Inverse difference	IB1Z	0.688	0.688	—	✅ PASS
Normalised inverse difference	NDRX	0.856	0.856	—	✅ PASS
Inverse difference moment	WF0Z	0.631	0.631	—	✅ PASS
Normalised inverse difference moment	1QCO	0.902	0.902	—	✅ PASS
Inverse variance	E8JP	0.0574	0.0574	—	✅ PASS
Correlation	NI2N	0.183	0.183	—	✅ PASS
Autocorrelation	QWB0	5.19	5.19	—	✅ PASS
Cluster tendency	DG8W	7.41	7.41	—	✅ PASS
Cluster shade	7NFM	17.4	17.4	—	✅ PASS
Cluster prominence	AE86	147	147	—	✅ PASS
Information correlation 1	R8DG	-0.0288	-0.0288	—	✅ PASS
Information correlation 2	JN9H	0.269	0.269	—	✅ PASS

GLRLM

Feature	Code	Calc	Ref	Tol	Status
Short runs emphasis	22OV	0.729	0.729	—	✅ PASS
Long runs emphasis	W4KF	2.76	2.76	—	✅ PASS
Low grey level run emphasis	V3SW	0.607	0.607	—	✅ PASS
High grey level run emphasis	G3QZ	9.64	9.64	—	✅ PASS
Short run low grey level emphasis	HTZT	0.372	0.372	—	✅ PASS
Short run high grey level emphasis	GD3A	8.67	8.67	—	✅ PASS
Long run low grey level emphasis	IVPO	2.16	2.16	—	✅ PASS
Long run high grey level emphasis	3KUM	15.6	15.6	—	✅ PASS
Grey level non-uniformity	R5YN	281	281	—	✅ PASS
Normalised grey level non-uniformity	OVBL	0.43	0.43	—	✅ PASS
Run length non-uniformity	W92Y	328	328	—	✅ PASS
Normalised run length non-uniformity	IC23	0.501	0.501	—	✅ PASS
Run percentage	9ZK5	0.68	0.68	—	✅ PASS
Grey level variance	8CE5	3.48	3.48	—	✅ PASS
Run length variance	SXLW	0.598	0.598	—	✅ PASS
Run entropy	HJ9O	2.62	2.62	—	✅ PASS

GLSZM

Feature	Code	Calc	Ref	Tol	Status
Small zone emphasis	P001	0.255	0.255	—	✅ PASS
Large zone emphasis	48P8	550	550	—	✅ PASS
Low grey level zone emphasis	XMSY	0.253	0.253	—	✅ PASS
High grey level zone emphasis	5GN9	15.6	15.6	—	✅ PASS
Small zone low grey level emphasis	5RAI	0.0256	0.0256	—	✅ PASS
Small zone high grey level emphasis	HW1V	2.76	2.76	—	✅ PASS
Large zone low grey level emphasis	YH51	503	503	—	✅ PASS
Large zone high grey level emphasis	J17V	1495	1.49e3	—	✅ PASS
Grey level non-uniformity	JNSA	1.4	1.4	—	✅ PASS
Normalised grey level non-uniformity	Y1RO	0.28	0.28	—	✅ PASS
Zone size non-uniformity	4JP3	1	1	—	✅ PASS
Normalised zone size non-uniformity	VB3A	0.2	0.2	—	✅ PASS
Zone percentage	P30P	0.0676	0.0676	—	✅ PASS
Grey level variance	BYLV	2.64	2.64	—	✅ PASS
Zone size variance	3NSA	331	331	—	✅ PASS
Zone size entropy	GU8N	2.32	2.32	—	✅ PASS

GLDZM

Feature	Code	Calc	Ref	Tol	Status
Small distance emphasis	0GBI	1	1	—	✅ PASS
Large distance emphasis	MB4I	1	1	—	✅ PASS
Low grey level zone emphasis	S1RA	0.253	0.253	—	✅ PASS
High grey level zone emphasis	K26C	15.6	15.6	—	✅ PASS
Small distance low grey level emphasis	RUVG	0.253	0.253	—	✅ PASS
Small distance high grey level emphasis	DKNJ	15.6	15.6	—	✅ PASS
Large distance low grey level emphasis	A7WM	0.253	0.253	—	✅ PASS
Large distance high grey level emphasis	KLTH	15.6	15.6	—	✅ PASS
Grey level non-uniformity	VFT7	1.4	1.4	—	✅ PASS
Normalised grey level non-uniformity	7HP3	0.28	0.28	—	✅ PASS
Zone distance non-uniformity	V294	5	5	—	✅ PASS
Normalised zone distance non-uniformity	IATH	1	1	—	✅ PASS
Zone percentage	VIWW	0.0676	0.0676	—	✅ PASS
Grey level variance	QK93	2.64	2.64	—	✅ PASS
Zone distance variance	7WT1	0	0	—	✅ PASS
Zone distance entropy	GBDU	1.92	1.92	—	✅ PASS

NGTDM

Feature	Code	Calc	Ref	Tol	Status
Coarseness	QCDE	0.0296	0.0296	—	✅ PASS
Contrast	65HE	0.584	0.584	—	✅ PASS
Busyness	NQ30	6.54	6.54	—	✅ PASS
Complexity	HDEZ	13.5	13.5	—	✅ PASS
Strength	1X9X	0.763	0.763	—	✅ PASS

NGLDM

Feature	Code	Calc	Ref	Tol	Status
Low dependence emphasis	SODN	0.045	0.045	—	✅ PASS
High dependence emphasis	IMOQ	109	109	—	✅ PASS
Low grey level count emphasis	TL9H	0.693	0.693	—	✅ PASS
High grey level count emphasis	OAE7	7.66	7.66	—	✅ PASS
Low dependence low grey level emphasis	EQ3F	0.00963	0.00963	—	✅ PASS
Low dependence high grey level emphasis	JA6D	0.736	0.736	—	✅ PASS
High dependence low grey level emphasis	NBZI	102	102	—	✅ PASS
High dependence high grey level emphasis	9QMG	235	235	—	✅ PASS
Grey level non-uniformity	FP8K	37.9	37.9	—	✅ PASS
Normalised grey level non-uniformity	5SPA	0.512	0.512	—	✅ PASS
Dependence count non-uniformity	Z87G	4.86	4.86	—	✅ PASS
Normalised dependence count non-uniformity	OKJI	0.0657	0.0657	—	✅ PASS
Dependence count percentage	6XV8	1	1	—	✅ PASS
Grey level variance	1PFV	3.05	3.05	—	✅ PASS
Dependence count variance	DNX2	22.1	22.1	—	✅ PASS
Dependence count entropy	FCBV	4.4	4.4	—	✅ PASS
Dependence count energy	CAS9	0.0533	0.0533	—	✅ PASS

Config C

Morphology

Feature	Code	Calc	Ref	Tol	Status
Volume	RNU0	3.675e+05	3.67e5	6e3	✅ PASS
Volume voxel counting	YEKZ	3.679e+05	3.68e5	6e3	✅ PASS
Surface area	C0JK	3.431e+04	3.43e4	400	✅ PASS
Surface to volume ratio	2PR5	0.0934	0.0934	0.0007	✅ PASS
Compactness 1	SKGS	0.03263	—	—	❗ REF.
Compactness 2	BQWJ	0.378	0.378	0.004	✅ PASS
Spherical disproportion	KRCK	1.38	1.38	0.01	✅ PASS
Sphericity	QCFX	0.723	0.723	0.003	✅ PASS
Asphericity	25C7	0.383	0.383	0.004	✅ PASS
Center of mass shift	KLMA	45.6	45.6	2.8	✅ PASS
Maximum 3D diameter	L0JK	125	125	1	✅ PASS
Major axis length	TDIC	93.3	93.3	0.5	✅ PASS
Minor axis length	P9VJ	82	82	0.5	✅ PASS
Least axis length	7J51	70.9	70.9	0.4	✅ PASS
Elongation	Q3CK	0.879	0.879	0.001	✅ PASS
Flatness	N17B	0.76	0.76	0.001	✅ PASS
Volume density (AABB)	PBX1	0.478	0.478	0.003	✅ PASS
Area density (AABB)	R59B	0.678	0.678	0.003	✅ PASS
Volume density (OMBB)	ZH1A	0.3408	—	—	❗ REF.
Area density (OMBB)	IQYR	0.5389	—	—	❗ REF.
Volume density (AEE)	6BDE	1.29	1.29	0.01	✅ PASS
Area density (AEE)	RDD2	1.62	1.62	0.01	✅ PASS
Volume density (MVEE)	SWZ1	0.496	—	—	❗ REF.
Area density (MVEE)	BRI8	0.8805	—	—	❗ REF.
Volume density (convex hull)	R3ER	0.834	0.834	0.002	✅ PASS
Area density (convex hull)	7T7F	1.13	1.13	0.01	✅ PASS

Intensity

Feature	Code	Calc	Ref	Tol	Status
Integrated intensity	99N0	-1.8e+07	-1.8e7	1.4e6	✅ PASS
Moran's I index	N365	0.0824	0.0824	0.0003	✅ PASS
Geary's C measure	NPT7	0.846	0.846	0.001	✅ PASS
Local intensity peak	VJGA	169	169	10	✅ PASS
Global intensity peak	0F91	180	180	5	✅ PASS
Mean intensity	Q4LE	-49	-49	2.9	✅ PASS
Intensity variance	ECT3	5.064e+04	5.06e4	1.4e3	✅ PASS
Intensity skewness	KE2A	-2.14	-2.14	0.05	✅ PASS
Intensity kurtosis	IPH6	3.53	3.53	0.23	✅ PASS
Median intensity	Y12H	40	40	0.4	✅ PASS
Minimum intensity	1GSF	-939	-939	4	✅ PASS
10th intensity percentile	QG58	-424	-424	14	✅ PASS
90th intensity percentile	8DWT	86	86	0.1	✅ PASS
Maximum intensity	84IY	393	393	10	✅ PASS
Intensity interquartile range	SALO	67	67	4.9	✅ PASS
Intensity range	2OJQ	1332	1.33e3	20	✅ PASS
Intensity Mean absolute deviation	4FUA	158	158	4	✅ PASS
Intensity Robust mean absolute deviation	1128	66.8	66.8	3.5	✅ PASS
Intensity Median absolute deviation	N72L	119	119	4	✅ PASS
Intensity Coefficient of variation	7TET	-4.59	-4.59	0.29	✅ PASS
Intensity Quartile coefficient of dispersion	9S40	1.03	1.03	0.4	✅ PASS
Intensity energy	N8CA	2.439e+09	2.44e9	1.2e8	✅ PASS
Root mean square intensity	5ZWQ	230	230	4	✅ PASS

Intensity Histogram

Feature	Code	Calc	Ref	Tol	Status
Mean discretised intensity	X6K6	38.6	38.6	0.2	✅ PASS
Discretised intensity variance	CH89	81.1	81.1	2.1	✅ PASS
Discretised intensity skewness	88K1	-2.14	-2.14	0.05	✅ PASS
Discretised intensity kurtosis	C3I7	3.52	3.52	0.23	✅ PASS
Median discretised intensity	WIFQ	42	42	—	✅ PASS
Minimum discretised intensity	1PR8	3	3	0.16	✅ PASS
10th discretised intensity percentile	1PR	24	24	0.7	✅ PASS
90th discretised intensity percentile	GPMT	44	44	—	✅ PASS
Maximum discretised intensity	3NCY	56	56	0.5	✅ PASS
Intensity histogram mode	AMMC	43	43	0.1	✅ PASS
Discretised intensity interquartile range	WR0O	3	3	0.21	✅ PASS
Discretised intensity range	5Z3W	53	53	0.6	✅ PASS
Intensity histogram mean absolute deviation	D2ZX	6.32	6.32	0.15	✅ PASS
Intensity histogram robust mean absolute deviation	WRZB	2.59	2.59	0.14	✅ PASS
Intensity histogram median absolute deviation	4RNL	4.75	4.75	0.12	✅ PASS
Intensity histogram coefficient of variation	CWYJ	0.234	0.234	0.005	✅ PASS
Intensity histogram quartile coefficient of dispersion	SLWD	0.0361	0.0361	0.0027	✅ PASS
Discretised intensity entropy	TLU2	3.73	3.73	0.04	✅ PASS
Discretised intensity uniformity	BJ5W	0.14	0.14	0.003	✅ PASS
Maximum histogram gradient	12CE	4746	4.75e3	30	✅ PASS
Maximum histogram gradient intensity	8E6O	41	41	—	✅ PASS
Minimum histogram gradient	VQB3	-4677	-4.68e3	50	✅ PASS
Minimum histogram gradient intensity	RHQZ	44	44	—	✅ PASS

Intensity-Volume Histogram

Feature	Code	Calc	Ref	Tol	Status
Volume at intensity fraction 0.10	BC2M_10	0.998	0.998	0.001	✅ PASS
Volume at intensity fraction 0.90	BC2M_90	0.000152	0.000152	2e-5	✅ PASS
Intensity at volume fraction 0.10	GBPN_10	88.8	88.8	0.2	✅ PASS
Intensity at volume fraction 0.90	GBPN_90	-421	-421	14	✅ PASS
Volume fraction difference between intensity 0.10 and 0.90 fractions	DDTU	0.997	0.997	0.001	✅ PASS
Intensity fraction difference between volume 0.10 and 0.90 fractions	CNV2	510	510	14	✅ PASS
Area under the IVH curve	9CMM	891.3	—	—	❗ REF.

GLCM

Feature	Code	Calc	Ref	Tol	Status
Joint maximum	GYBY	0.111	0.111	0.002	✅ PASS
Joint average	60VM	39	39	0.2	✅ PASS
Joint variance	UR99	73.8	73.8	2	✅ PASS
Joint entropy	TU9B	6.42	6.42	0.06	✅ PASS
Difference average	TF7R	2.16	2.16	0.05	✅ PASS
Difference variance	D3YU	14.4	14.4	0.5	✅ PASS
Difference entropy	NTRS	2.64	2.64	0.03	✅ PASS
Sum average	ZGXS	78	78	0.3	✅ PASS
Sum variance	OEEB	276	276	8	✅ PASS
Sum entropy	P6QZ	4.56	4.56	0.04	✅ PASS
Angular second moment	8ZQL	0.0447	0.0447	0.001	✅ PASS
Contrast	ACUI	19.1	19.1	0.7	✅ PASS
Dissimilarity	8S9J	2.16	2.16	0.05	✅ PASS
Inverse difference	IB1Z	0.583	0.583	0.004	✅ PASS
Normalised inverse difference	NDRX	0.965	0.966	0.001	✅ PASS
Inverse difference moment	WF0Z	0.548	0.548	0.004	✅ PASS
Normalised inverse difference moment	1QCO	0.994	0.994	0.001	✅ PASS
Inverse variance	E8JP	0.39	0.39	0.003	✅ PASS
Correlation	NI2N	0.871	0.871	0.001	✅ PASS
Autocorrelation	QWB0	1583	1.58e3	10	✅ PASS
Cluster tendency	DG8W	276	276	8	✅ PASS
Cluster shade	7NFM	-1.063e+04	-1.06e4	300	✅ PASS
Cluster prominence	AE86	5.696e+05	5.7e5	1.1e4	✅ PASS
Information correlation 1	R8DG	-0.228	-0.228	0.001	✅ PASS
Information correlation 2	JN9H	0.899	0.899	0.001	✅ PASS

GLRLM

Feature	Code	Calc	Ref	Tol	Status
Short runs emphasis	22OV	0.787	0.787	0.003	✅ PASS
Long runs emphasis	W4KF	3.28	3.28	0.04	✅ PASS
Low grey level run emphasis	V3SW	0.00155	0.00155	5e-5	✅ PASS
High grey level run emphasis	G3QZ	1473	1.47e3	10	✅ PASS
Short run low grey level emphasis	HTZT	0.00136	0.00136	5e-5	✅ PASS
Short run high grey level emphasis	GD3A	1100	1.1e3	10	✅ PASS
Long run low grey level emphasis	IVPO	0.00314	0.00314	4e-5	✅ PASS
Long run high grey level emphasis	3KUM	5525	5.53e3	80	✅ PASS
Grey level non-uniformity	R5YN	4.13e+04	4.13e4	100	✅ PASS
Normalised grey level non-uniformity	OVBL	0.102	0.102	0.003	✅ PASS
Run length non-uniformity	W92Y	2.336e+05	2.34e5	6e3	✅ PASS
Normalised run length non-uniformity	IC23	0.575	0.575	0.004	✅ PASS
Run percentage	9ZK5	0.679	0.679	0.003	✅ PASS
Grey level variance	8CE5	101	101	3	✅ PASS
Run length variance	SXLW	1.11	1.11	0.02	✅ PASS
Run entropy	HJ9O	5.35	5.35	0.03	✅ PASS

GLSZM

Feature	Code	Calc	Ref	Tol	Status
Small zone emphasis	P001	0.695	0.695	0.001	✅ PASS
Large zone emphasis	48P8	3.893e+04	3.89e4	900	✅ PASS
Low grey level zone emphasis	XMSY	0.00235	0.00235	6e-5	✅ PASS
High grey level zone emphasis	5GN9	971	971	7	✅ PASS
Small zone low grey level emphasis	5RAI	0.0016	0.0016	4e-5	✅ PASS
Small zone high grey level emphasis	HW1V	657	657	4	✅ PASS
Large zone low grey level emphasis	YH51	21.6	21.6	0.5	✅ PASS
Large zone high grey level emphasis	J17V	7.071e+07	7.07e7	1.5e6	✅ PASS
Grey level non-uniformity	JNSA	195	195	6	✅ PASS
Normalised grey level non-uniformity	Y1RO	0.0286	0.0286	0.0003	✅ PASS
Zone size non-uniformity	4JP3	3043	3.04e3	100	✅ PASS
Normalised zone size non-uniformity	VB3A	0.447	0.447	0.001	✅ PASS
Zone percentage	P30P	0.148	0.148	0.003	✅ PASS
Grey level variance	BYLV	106	106	1	✅ PASS
Zone size variance	3NSA	3.888e+04	3.89e4	900	✅ PASS
Zone size entropy	GU8N	7	7	0.01	✅ PASS

GLDZM

Feature	Code	Calc	Ref	Tol	Status
Small distance emphasis	0GBI	0.531	0.531	0.006	✅ PASS
Large distance emphasis	MB4I	11	11	0.3	✅ PASS
Low grey level zone emphasis	S1RA	0.00235	0.00235	6e-5	✅ PASS
High grey level zone emphasis	K26C	971	971	7	✅ PASS
Small distance low grey level emphasis	RUVG	0.00149	0.00149	4e-5	✅ PASS
Small distance high grey level emphasis	DKNJ	476	476	11	✅ PASS
Large distance low grey level emphasis	A7WM	0.0154	0.0154	0.0005	✅ PASS
Large distance high grey level emphasis	KLTH	1.336e+04	1.34e4	200	✅ PASS
Grey level non-uniformity	VFT7	195	195	6	✅ PASS
Normalised grey level non-uniformity	7HP3	0.0286	0.0286	0.0003	✅ PASS
Zone distance non-uniformity	V294	1866	1.87e3	40	✅ PASS
Normalised zone distance non-uniformity	IATH	0.274	0.274	0.005	✅ PASS
Zone percentage	VIWW	0.148	0.148	0.003	✅ PASS
Grey level variance	QK93	106	106	1	✅ PASS
Zone distance variance	7WT1	4.6	4.6	0.06	✅ PASS
Zone distance entropy	GBDU	7.56	7.56	0.03	✅ PASS

NGTDM

Feature	Code	Calc	Ref	Tol	Status
Coarseness	QCDE	0.000216	0.000216	4e-6	✅ PASS
Contrast	65HE	0.0873	0.0873	0.0019	✅ PASS
Busyness	NQ30	1.39	1.39	0.01	✅ PASS
Complexity	HDEZ	1809	1.81e3	60	✅ PASS
Strength	1X9X	0.651	0.651	0.015	✅ PASS

NGLDM

Feature	Code	Calc	Ref	Tol	Status
Low dependence emphasis	SODN	0.137	0.137	0.003	✅ PASS
High dependence emphasis	IMOQ	126	126	2	✅ PASS
Low grey level count emphasis	TL9H	0.0013	0.0013	4e-5	✅ PASS
High grey level count emphasis	OAE7	1568	1.57e3	10	✅ PASS
Low dependence low grey level emphasis	EQ3F	0.000306	0.000306	1.2e-5	✅ PASS
Low dependence high grey level emphasis	JA6D	141	141	2	✅ PASS
High dependence low grey level emphasis	NBZI	0.0828	0.0828	0.0003	✅ PASS
High dependence high grey level emphasis	9QMG	2.267e+05	2.27e5	3e3	✅ PASS
Grey level non-uniformity	FP8K	6417	6.42e3	10	✅ PASS
Normalised grey level non-uniformity	5SPA	0.14	0.14	0.003	✅ PASS
Dependence count non-uniformity	Z87G	2447	2.45e3	60	✅ PASS
Normalised dependence count non-uniformity	OKJI	0.0532	0.0532	0.0005	✅ PASS
Dependence count percentage	6XV8	1	1	—	✅ PASS
Grey level variance	1PFV	81.1	81.1	2.1	✅ PASS
Dependence count variance	DNX2	39.2	39.2	0.1	✅ PASS
Dependence count entropy	FCBV	7.54	7.54	0.03	✅ PASS
Dependence count energy	CAS9	0.00789	0.00789	0.00011	✅ PASS

Config D

Morphology

Feature	Code	Calc	Ref	Tol	Status
Volume	RNU0	3.675e+05	3.67e5	6e3	✅ PASS
Volume voxel counting	YEKZ	3.679e+05	3.68e5	6e3	✅ PASS
Surface area	C0JK	3.431e+04	3.43e4	400	✅ PASS
Surface to volume ratio	2PR5	0.0934	0.0934	0.0007	✅ PASS
Compactness 1	SKGS	0.0326	0.0326	0.0002	✅ PASS
Compactness 2	BQWJ	0.378	0.378	0.004	✅ PASS
Spherical disproportion	KRCK	1.38	1.38	0.01	✅ PASS
Sphericity	QCFX	0.723	0.723	0.003	✅ PASS
Asphericity	25C7	0.383	0.383	0.004	✅ PASS
Center of mass shift	KLMA	64.9	64.9	2.8	✅ PASS
Maximum 3D diameter	L0JK	125	125	1	✅ PASS
Major axis length	TDIC	93.3	93.3	0.5	✅ PASS
Minor axis length	P9VJ	82	82	0.5	✅ PASS
Least axis length	7J51	70.9	70.9	0.4	✅ PASS
Elongation	Q3CK	0.879	0.879	0.001	✅ PASS
Flatness	N17B	0.76	0.76	0.001	✅ PASS
Volume density (AABB)	PBX1	0.478	0.478	0.003	✅ PASS
Area density (AABB)	R59B	0.678	0.678	0.003	✅ PASS
Volume density (OMBB)	ZH1A	0.3408	—	—	❗ REF.
Area density (OMBB)	IQYR	0.5389	—	—	❗ REF.
Volume density (AEE)	6BDE	1.29	1.29	0.01	✅ PASS
Area density (AEE)	RDD2	1.62	1.62	0.01	✅ PASS
Volume density (MVEE)	SWZ1	0.496	—	—	❗ REF.
Area density (MVEE)	BRI8	0.8805	—	—	❗ REF.
Volume density (convex hull)	R3ER	0.834	0.834	0.002	✅ PASS
Area density (convex hull)	7T7F	1.13	1.13	0.01	✅ PASS

Intensity

Feature	Code	Calc	Ref	Tol	Status
Integrated intensity	99N0	-8.642e+06	-8.64e6	1.56e6	✅ PASS
Moran's I index	N365	0.0622	0.0622	0.0013	✅ PASS
Geary's C measure	NPT7	0.851	0.851	0.001	✅ PASS
Local intensity peak	VJGA	201	201	10	✅ PASS
Global intensity peak	0F91	201	201	5	✅ PASS
Mean intensity	Q4LE	-23.5	-23.5	3.9	✅ PASS
Intensity variance	ECT3	3.279e+04	3.28e4	2.1e3	✅ PASS
Intensity skewness	KE2A	-2.28	-2.28	0.06	✅ PASS
Intensity kurtosis	IPH6	4.35	4.35	0.32	✅ PASS
Median intensity	Y12H	42	42	0.4	✅ PASS
Minimum intensity	1GSF	-724	-724	12	✅ PASS
10th intensity percentile	QG58	-304	-304	20	✅ PASS
90th intensity percentile	8DWT	86	86	0.1	✅ PASS
Maximum intensity	84IY	521	521	22	✅ PASS
Intensity interquartile range	SALO	57	57	4.1	✅ PASS
Intensity range	2OJQ	1245	1.24e3	40	✅ PASS
Intensity Mean absolute deviation	4FUA	123	123	6	✅ PASS
Intensity Robust mean absolute deviation	1128	46.8	46.8	3.6	✅ PASS
Intensity Median absolute deviation	N72L	94.7	94.7	3.8	✅ PASS
Intensity Coefficient of variation	7TET	-7.7	-7.7	1.01	✅ PASS
Intensity Quartile coefficient of dispersion	9S40	0.74	0.74	0.011	✅ PASS
Intensity energy	N8CA	1.482e+09	1.48e9	1.4e8	✅ PASS
Root mean square intensity	5ZWQ	183	183	7	✅ PASS

Intensity Histogram

Feature	Code	Calc	Ref	Tol	Status
Mean discretised intensity	X6K6	18.5	18.5	0.5	✅ PASS
Discretised intensity variance	CH89	21.7	21.7	0.4	✅ PASS
Discretised intensity skewness	88K1	-2.27	-2.27	0.06	✅ PASS
Discretised intensity kurtosis	C3I7	4.31	4.31	0.32	✅ PASS
Median discretised intensity	WIFQ	20	20	0.5	✅ PASS
Minimum discretised intensity	1PR8	1	1	—	✅ PASS
10th discretised intensity percentile	1PR	11	11	0.7	✅ PASS
90th discretised intensity percentile	GPMT	21	21	0.5	✅ PASS
Maximum discretised intensity	3NCY	32	32	—	✅ PASS
Intensity histogram mode	AMMC	20	20	0.4	✅ PASS
Discretised intensity interquartile range	WR0O	2	2	0.06	✅ PASS
Discretised intensity range	5Z3W	31	31	—	✅ PASS
Intensity histogram mean absolute deviation	D2ZX	3.15	3.15	0.05	✅ PASS
Intensity histogram robust mean absolute deviation	WRZB	1.33	1.33	0.06	✅ PASS
Intensity histogram median absolute deviation	4RNL	2.41	2.41	0.04	✅ PASS
Intensity histogram coefficient of variation	CWYJ	0.252	0.252	0.006	✅ PASS
Intensity histogram quartile coefficient of dispersion	SLWD	0.05	0.05	0.0021	✅ PASS
Discretised intensity entropy	TLU2	2.94	2.94	0.01	✅ PASS
Discretised intensity uniformity	BJ5W	0.229	0.229	0.003	✅ PASS
Maximum histogram gradient	12CE	7263	7.26e3	200	✅ PASS
Maximum histogram gradient intensity	8E6O	19	19	0.4	✅ PASS
Minimum histogram gradient	VQB3	-6674	-6.67e3	230	✅ PASS
Minimum histogram gradient intensity	RHQZ	22	22	0.4	✅ PASS

Intensity-Volume Histogram

Feature	Code	Calc	Ref	Tol	Status
Volume at intensity fraction 0.10	BC2M_10	0.972	0.972	0.003	✅ PASS
Volume at intensity fraction 0.90	BC2M_90	0.00009	9e-5	0.000415	✅ PASS
Intensity at volume fraction 0.10	GBPN_10	87	87	0.1	✅ PASS
Intensity at volume fraction 0.90	GBPN_90	-303	-303	20	✅ PASS
Volume fraction difference between intensity 0.10 and 0.90 fractions	DDTU	0.971	0.971	0.001	✅ PASS
Intensity fraction difference between volume 0.10 and 0.90 fractions	CNV2	390	390	20	✅ PASS
Area under the IVH curve	9CMM	701	—	—	❗ REF.

GLCM

Feature	Code	Calc	Ref	Tol	Status
Joint maximum	GYBY	0.232	0.232	0.007	✅ PASS
Joint average	60VM	18.9	18.9	0.5	✅ PASS
Joint variance	UR99	17.6	17.6	0.4	✅ PASS
Joint entropy	TU9B	4.96	4.96	0.03	✅ PASS
Difference average	TF7R	1.29	1.29	0.01	✅ PASS
Difference variance	D3YU	5.38	5.38	0.11	✅ PASS
Difference entropy	NTRS	2.14	2.14	0.01	✅ PASS
Sum average	ZGXS	37.7	37.7	0.8	✅ PASS
Sum variance	OEEB	63.5	63.5	1.3	✅ PASS
Sum entropy	P6QZ	3.68	3.68	0.02	✅ PASS
Angular second moment	8ZQL	0.109	0.109	0.003	✅ PASS
Contrast	ACUI	7.05	7.05	0.13	✅ PASS
Dissimilarity	8S9J	1.29	1.29	0.01	✅ PASS
Inverse difference	IB1Z	0.682	0.682	0.003	✅ PASS
Normalised inverse difference	NDRX	0.965	0.965	0.001	✅ PASS
Inverse difference moment	WF0Z	0.657	0.657	0.003	✅ PASS
Normalised inverse difference moment	1QCO	0.994	0.994	0.001	✅ PASS
Inverse variance	E8JP	0.34	0.34	0.005	✅ PASS
Correlation	NI2N	0.8	0.8	0.005	✅ PASS
Autocorrelation	QWB0	370	370	16	✅ PASS
Cluster tendency	DG8W	63.5	63.5	1.3	✅ PASS
Cluster shade	7NFM	-1275	-1.28e3	40	✅ PASS
Cluster prominence	AE86	3.574e+04	3.57e4	1.5e3	✅ PASS
Information correlation 1	R8DG	-0.225	-0.225	0.003	✅ PASS
Information correlation 2	JN9H	0.846	0.846	0.003	✅ PASS

GLRLM

Feature	Code	Calc	Ref	Tol	Status
Short runs emphasis	22OV	0.736	0.736	0.001	✅ PASS
Long runs emphasis	W4KF	6.56	6.56	0.18	✅ PASS
Low grey level run emphasis	V3SW	0.0257	0.0257	0.0012	✅ PASS
High grey level run emphasis	G3QZ	326	326	17	✅ PASS
Short run low grey level emphasis	HTZT	0.0232	0.0232	0.001	✅ PASS
Short run high grey level emphasis	GD3A	219	219	13	✅ PASS
Long run low grey level emphasis	IVPO	0.0478	0.0478	0.0031	✅ PASS
Long run high grey level emphasis	3KUM	2626	2.63e3	30	✅ PASS
Grey level non-uniformity	R5YN	4.277e+04	4.28e4	200	✅ PASS
Normalised grey level non-uniformity	OVBL	0.134	0.134	0.002	✅ PASS
Run length non-uniformity	W92Y	1.604e+05	1.6e5	3e3	✅ PASS
Normalised run length non-uniformity	IC23	0.501	0.501	0.001	✅ PASS
Run percentage	9ZK5	0.554	0.554	0.005	✅ PASS
Grey level variance	8CE5	31.4	31.4	0.4	✅ PASS
Run length variance	SXLW	3.29	3.29	0.13	✅ PASS
Run entropy	HJ9O	5.08	5.08	0.02	✅ PASS

GLSZM

Feature	Code	Calc	Ref	Tol	Status
Small zone emphasis	P001	0.637	0.637	0.005	✅ PASS
Large zone emphasis	48P8	9.908e+04	9.91e4	2.8e3	✅ PASS
Low grey level zone emphasis	XMSY	0.0409	0.0409	0.0005	✅ PASS
High grey level zone emphasis	5GN9	188	188	10	✅ PASS
Small zone low grey level emphasis	5RAI	0.0248	0.0248	0.0004	✅ PASS
Small zone high grey level emphasis	HW1V	117	117	7	✅ PASS
Large zone low grey level emphasis	YH51	241	241	14	✅ PASS
Large zone high grey level emphasis	J17V	4.14e+07	4.14e7	3e5	✅ PASS
Grey level non-uniformity	JNSA	212	212	6	✅ PASS
Normalised grey level non-uniformity	Y1RO	0.0491	0.0491	0.0008	✅ PASS
Zone size non-uniformity	4JP3	1629	1.63e3	10	✅ PASS
Normalised zone size non-uniformity	VB3A	0.377	0.377	0.006	✅ PASS
Zone percentage	P30P	0.0972	0.0972	0.0007	✅ PASS
Grey level variance	BYLV	32.7	32.7	1.6	✅ PASS
Zone size variance	3NSA	9.897e+04	9.9e4	2.8e3	✅ PASS
Zone size entropy	GU8N	6.52	6.52	0.01	✅ PASS

GLDZM

Feature	Code	Calc	Ref	Tol	Status
Small distance emphasis	0GBI	0.579	0.579	0.004	✅ PASS
Large distance emphasis	MB4I	10.3	10.3	0.1	✅ PASS
Low grey level zone emphasis	S1RA	0.0409	0.0409	0.0005	✅ PASS
High grey level zone emphasis	K26C	188	188	10	✅ PASS
Small distance low grey level emphasis	RUVG	0.0302	0.0302	0.0006	✅ PASS
Small distance high grey level emphasis	DKNJ	99.3	99.3	5.1	✅ PASS
Large distance low grey level emphasis	A7WM	0.183	0.183	0.004	✅ PASS
Large distance high grey level emphasis	KLTH	2619	2.62e3	110	✅ PASS
Grey level non-uniformity	VFT7	212	212	6	✅ PASS
Normalised grey level non-uniformity	7HP3	0.0491	0.0491	0.0008	✅ PASS
Zone distance non-uniformity	V294	1369	1.37e3	20	✅ PASS
Normalised zone distance non-uniformity	IATH	0.317	0.317	0.004	✅ PASS
Zone percentage	VIWW	0.0972	0.0972	0.0007	✅ PASS
Grey level variance	QK93	32.7	32.7	1.6	✅ PASS
Zone distance variance	7WT1	4.61	4.61	0.04	✅ PASS
Zone distance entropy	GBDU	6.61	6.61	0.03	✅ PASS

NGTDM

Feature	Code	Calc	Ref	Tol	Status
Coarseness	QCDE	0.000208	0.000208	4e-6	✅ PASS
Contrast	65HE	0.046	0.046	0.0005	✅ PASS
Busyness	NQ30	5.14	5.14	0.14	✅ PASS
Complexity	HDEZ	400	400	5	✅ PASS
Strength	1X9X	0.162	0.162	0.008	✅ PASS

NGLDM

Feature	Code	Calc	Ref	Tol	Status
Low dependence emphasis	SODN	0.0912	0.0912	0.0007	✅ PASS
High dependence emphasis	IMOQ	223	223	5	✅ PASS
Low grey level count emphasis	TL9H	0.0168	0.0168	0.0009	✅ PASS
High grey level count emphasis	OAE7	364	364	16	✅ PASS
Low dependence low grey level emphasis	EQ3F	0.00357	0.00357	4e-5	✅ PASS
Low dependence high grey level emphasis	JA6D	18.9	18.9	1.1	✅ PASS
High dependence low grey level emphasis	NBZI	0.798	0.798	0.072	✅ PASS
High dependence high grey level emphasis	9QMG	9.276e+04	9.28e4	1.3e3	✅ PASS
Grey level non-uniformity	FP8K	1.017e+04	1.02e4	300	✅ PASS
Normalised grey level non-uniformity	5SPA	0.229	0.229	0.003	✅ PASS
Dependence count non-uniformity	Z87G	1837	1.84e3	30	✅ PASS
Normalised dependence count non-uniformity	OKJI	0.0413	0.0413	0.0003	✅ PASS
Dependence count percentage	6XV8	1	1	—	✅ PASS
Grey level variance	1PFV	21.7	21.7	0.4	✅ PASS
Dependence count variance	DNX2	63.9	63.9	1.3	✅ PASS
Dependence count entropy	FCBV	6.98	6.98	0.01	✅ PASS
Dependence count energy	CAS9	0.0113	0.0113	0.0002	✅ PASS

Config E

Morphology

Feature	Code	Calc	Ref	Tol	Status
Volume	RNU0	3.675e+05	3.67e5	6e3	✅ PASS
Volume voxel counting	YEKZ	3.679e+05	3.68e5	6e3	✅ PASS
Surface area	C0JK	3.431e+04	3.43e4	400	✅ PASS
Surface to volume ratio	2PR5	0.0934	0.0934	0.0007	✅ PASS
Compactness 1	SKGS	0.0326	0.0326	0.0002	✅ PASS
Compactness 2	BQWJ	0.378	0.378	0.004	✅ PASS
Spherical disproportion	KRCK	1.38	1.38	0.01	✅ PASS
Sphericity	QCFX	0.723	0.723	0.003	✅ PASS
Asphericity	25C7	0.383	0.383	0.004	✅ PASS
Center of mass shift	KLMA	68.5	68.5	2.1	✅ PASS
Maximum 3D diameter	L0JK	125	125	1	✅ PASS
Major axis length	TDIC	93.3	93.3	0.5	✅ PASS
Minor axis length	P9VJ	82	82	0.5	✅ PASS
Least axis length	7J51	70.9	70.9	0.4	✅ PASS
Elongation	Q3CK	0.879	0.879	0.001	✅ PASS
Flatness	N17B	0.76	0.76	0.001	✅ PASS
Volume density (AABB)	PBX1	0.478	0.478	0.003	✅ PASS
Area density (AABB)	R59B	0.678	0.678	0.003	✅ PASS
Volume density (OMBB)	ZH1A	0.3408	—	—	❗ REF.
Area density (OMBB)	IQYR	0.5389	—	—	❗ REF.
Volume density (AEE)	6BDE	1.29	1.29	0.01	✅ PASS
Area density (AEE)	RDD2	1.62	1.62	0.01	✅ PASS
Volume density (MVEE)	SWZ1	0.496	—	—	❗ REF.
Area density (MVEE)	BRI8	0.8805	—	—	❗ REF.
Volume density (convex hull)	R3ER	0.834	0.834	0.002	✅ PASS
Area density (convex hull)	7T7F	1.13	1.13	0.01	✅ PASS

Intensity

Feature	Code	Calc	Ref	Tol	Status
Integrated intensity	99N0	-8.332e+06	-8.31e6	1.6e6	✅ PASS
Moran's I index	N365	0.0596	0.0596	0.0014	✅ PASS
Geary's C measure	NPT7	0.853	0.853	0.001	✅ PASS
Local intensity peak	VJGA	181	181	13	✅ PASS
Global intensity peak	0F91	181	181	5	✅ PASS
Mean intensity	Q4LE	-22.7	-22.6	4.1	✅ PASS
Intensity variance	ECT3	3.513e+04	3.51e4	2.2e3	✅ PASS
Intensity skewness	KE2A	-2.3	-2.3	0.07	✅ PASS
Intensity kurtosis	IPH6	4.44	4.44	0.33	✅ PASS
Median intensity	Y12H	43	43	0.5	✅ PASS
Minimum intensity	1GSF	-744	-743	13	✅ PASS
10th intensity percentile	QG58	-311	-310	21	✅ PASS
90th intensity percentile	8DWT	93	93	0.2	✅ PASS
Maximum intensity	84IY	345	345	9	✅ PASS
Intensity interquartile range	SALO	62	62	3.5	✅ PASS
Intensity range	2OJQ	1089	1.09e3	30	✅ PASS
Intensity Mean absolute deviation	4FUA	125	125	6	✅ PASS
Intensity Robust mean absolute deviation	1128	46.5	46.5	3.7	✅ PASS
Intensity Median absolute deviation	N72L	97.9	97.9	3.9	✅ PASS
Intensity Coefficient of variation	7TET	-8.27	-8.28	0.95	✅ PASS
Intensity Quartile coefficient of dispersion	9S40	0.795	0.795	0.337	✅ PASS
Intensity energy	N8CA	1.586e+09	1.58e9	1.4e8	✅ PASS
Root mean square intensity	5ZWQ	189	189	7	✅ PASS

Intensity Histogram

Feature	Code	Calc	Ref	Tol	Status
Mean discretised intensity	X6K6	21.7	21.7	0.3	✅ PASS
Discretised intensity variance	CH89	30.5	30.4	0.8	✅ PASS
Discretised intensity skewness	88K1	-2.29	-2.29	0.07	✅ PASS
Discretised intensity kurtosis	C3I7	4.4	4.4	0.33	✅ PASS
Median discretised intensity	WIFQ	24	24	0.2	✅ PASS
Minimum discretised intensity	1PR8	1	1	—	✅ PASS
10th discretised intensity percentile	1PR	13	13	0.7	✅ PASS
90th discretised intensity percentile	GPMT	25	25	0.2	✅ PASS
Maximum discretised intensity	3NCY	32	32	—	✅ PASS
Intensity histogram mode	AMMC	24	24	0.1	✅ PASS
Discretised intensity interquartile range	WR0O	1	1	0.06	✅ PASS
Discretised intensity range	5Z3W	31	31	—	✅ PASS
Intensity histogram mean absolute deviation	D2ZX	3.69	3.69	0.1	✅ PASS
Intensity histogram robust mean absolute deviation	WRZB	1.46	1.46	0.09	✅ PASS
Intensity histogram median absolute deviation	4RNL	2.89	2.89	0.07	✅ PASS
Intensity histogram coefficient of variation	CWYJ	0.254	0.254	0.006	✅ PASS
Intensity histogram quartile coefficient of dispersion	SLWD	0.0213	0.0213	0.0015	✅ PASS
Discretised intensity entropy	TLU2	3.22	3.22	0.02	✅ PASS
Discretised intensity uniformity	BJ5W	0.184	0.184	0.001	✅ PASS
Maximum histogram gradient	12CE	6010	6.01e3	130	✅ PASS
Maximum histogram gradient intensity	8E6O	23	23	0.2	✅ PASS
Minimum histogram gradient	VQB3	-6110	-6.11e3	180	✅ PASS
Minimum histogram gradient intensity	RHQZ	25	25	0.2	✅ PASS

Intensity-Volume Histogram

Feature	Code	Calc	Ref	Tol	Status
Volume at intensity fraction 0.10	BC2M_10	0.975	0.975	0.002	✅ PASS
Volume at intensity fraction 0.90	BC2M_90	0.000157	0.000157	0.000248	✅ PASS
Intensity at volume fraction 0.10	GBPN_10	770	770	5	✅ PASS
Intensity at volume fraction 0.90	GBPN_90	399	399	17	✅ PASS
Volume fraction difference between intensity 0.10 and 0.90 fractions	DDTU	0.975	0.974	0.001	✅ PASS
Intensity fraction difference between volume 0.10 and 0.90 fractions	CNV2	371	371	13	✅ PASS
Area under the IVH curve	9CMM	662.4	—	—	❗ REF.

GLCM

Feature	Code	Calc	Ref	Tol	Status
Joint maximum	GYBY	0.153	0.153	0.003	✅ PASS
Joint average	60VM	22.1	22.1	0.3	✅ PASS
Joint variance	UR99	24.5	24.4	0.9	✅ PASS
Joint entropy	TU9B	5.61	5.61	0.03	✅ PASS
Difference average	TF7R	1.7	1.7	0.01	✅ PASS
Difference variance	D3YU	8.24	8.23	0.06	✅ PASS
Difference entropy	NTRS	2.4	2.4	0.01	✅ PASS
Sum average	ZGXS	44.3	44.3	0.4	✅ PASS
Sum variance	OEEB	86.8	86.7	3.3	✅ PASS
Sum entropy	P6QZ	3.97	3.97	0.02	✅ PASS
Angular second moment	8ZQL	0.0635	0.0635	0.0009	✅ PASS
Contrast	ACUI	11.1	11.1	0.1	✅ PASS
Dissimilarity	8S9J	1.7	1.7	0.01	✅ PASS
Inverse difference	IB1Z	0.608	0.608	0.001	✅ PASS
Normalised inverse difference	NDRX	0.955	0.955	0.001	✅ PASS
Inverse difference moment	WF0Z	0.577	0.577	0.001	✅ PASS
Normalised inverse difference moment	1QCO	0.99	0.99	0.001	✅ PASS
Inverse variance	E8JP	0.41	0.41	0.004	✅ PASS
Correlation	NI2N	0.773	0.773	0.006	✅ PASS
Autocorrelation	QWB0	509	509	8	✅ PASS
Cluster tendency	DG8W	86.8	86.7	3.3	✅ PASS
Cluster shade	7NFM	-2080	-2.08e3	70	✅ PASS
Cluster prominence	AE86	6.919e+04	6.9e4	2.1e3	✅ PASS
Information correlation 1	R8DG	-0.175	-0.175	0.003	✅ PASS
Information correlation 2	JN9H	0.813	0.813	0.004	✅ PASS

GLRLM

Feature	Code	Calc	Ref	Tol	Status
Short runs emphasis	22OV	0.777	0.777	0.001	✅ PASS
Long runs emphasis	W4KF	3.52	3.52	0.07	✅ PASS
Low grey level run emphasis	V3SW	0.0204	0.0204	0.0008	✅ PASS
High grey level run emphasis	G3QZ	471	471	9	✅ PASS
Short run low grey level emphasis	HTZT	0.0187	0.0186	0.0007	✅ PASS
Short run high grey level emphasis	GD3A	347	347	7	✅ PASS
Long run low grey level emphasis	IVPO	0.0313	0.0311	0.0016	✅ PASS
Long run high grey level emphasis	3KUM	1889	1.89e3	20	✅ PASS
Grey level non-uniformity	R5YN	5.195e+04	5.19e4	200	✅ PASS
Normalised grey level non-uniformity	OVBL	0.135	0.135	0.003	✅ PASS
Run length non-uniformity	W92Y	2.151e+05	2.15e5	4e3	✅ PASS
Normalised run length non-uniformity	IC23	0.56	0.56	0.001	✅ PASS
Run percentage	9ZK5	0.664	0.664	0.003	✅ PASS
Grey level variance	8CE5	39.7	39.7	0.9	✅ PASS
Run length variance	SXLW	1.25	1.25	0.05	✅ PASS
Run entropy	HJ9O	4.87	4.87	0.03	✅ PASS

GLSZM

Feature	Code	Calc	Ref	Tol	Status
Small zone emphasis	P001	0.676	0.676	0.003	✅ PASS
Large zone emphasis	48P8	5.856e+04	5.86e4	800	✅ PASS
Low grey level zone emphasis	XMSY	0.034	0.034	0.0004	✅ PASS
High grey level zone emphasis	5GN9	286	286	6	✅ PASS
Small zone low grey level emphasis	5RAI	0.0223	0.0224	0.0004	✅ PASS
Small zone high grey level emphasis	HW1V	186	186	4	✅ PASS
Large zone low grey level emphasis	YH51	105	105	4	✅ PASS
Large zone high grey level emphasis	J17V	3.356e+07	3.36e7	3e5	✅ PASS
Grey level non-uniformity	JNSA	231	231	6	✅ PASS
Normalised grey level non-uniformity	Y1RO	0.0414	0.0414	0.0003	✅ PASS
Zone size non-uniformity	4JP3	2367	2.37e3	40	✅ PASS
Normalised zone size non-uniformity	VB3A	0.424	0.424	0.004	✅ PASS
Zone percentage	P30P	0.126	0.126	0.001	✅ PASS
Grey level variance	BYLV	50.8	50.8	0.9	✅ PASS
Zone size variance	3NSA	5.85e+04	5.85e4	800	✅ PASS
Zone size entropy	GU8N	6.57	6.57	0.01	✅ PASS

GLDZM

Feature	Code	Calc	Ref	Tol	Status
Small distance emphasis	0GBI	0.527	0.527	0.004	✅ PASS
Large distance emphasis	MB4I	12.6	12.6	0.1	✅ PASS
Low grey level zone emphasis	S1RA	0.034	0.034	0.0004	✅ PASS
High grey level zone emphasis	K26C	286	286	6	✅ PASS
Small distance low grey level emphasis	RUVG	0.0229	0.0228	0.0003	✅ PASS
Small distance high grey level emphasis	DKNJ	136	136	4	✅ PASS
Large distance low grey level emphasis	A7WM	0.178	0.179	0.004	✅ PASS
Large distance high grey level emphasis	KLTH	4854	4.85e3	60	✅ PASS
Grey level non-uniformity	VFT7	231	231	6	✅ PASS
Normalised grey level non-uniformity	7HP3	0.0414	0.0414	0.0003	✅ PASS
Zone distance non-uniformity	V294	1503	1.5e3	30	✅ PASS
Normalised zone distance non-uniformity	IATH	0.269	0.269	0.003	✅ PASS
Zone percentage	VIWW	0.126	0.126	0.001	✅ PASS
Grey level variance	QK93	50.8	50.8	0.9	✅ PASS
Zone distance variance	7WT1	5.56	5.56	0.05	✅ PASS
Zone distance entropy	GBDU	7.06	7.06	0.01	✅ PASS

NGTDM

Feature	Code	Calc	Ref	Tol	Status
Coarseness	QCDE	0.000188	0.000188	4e-6	✅ PASS
Contrast	65HE	0.0753	0.0752	0.0019	✅ PASS
Busyness	NQ30	4.65	4.65	0.1	✅ PASS
Complexity	HDEZ	574	574	1	✅ PASS
Strength	1X9X	0.167	0.167	0.006	✅ PASS

NGLDM

Feature	Code	Calc	Ref	Tol	Status
Low dependence emphasis	SODN	0.118	0.118	0.001	✅ PASS
High dependence emphasis	IMOQ	134	134	3	✅ PASS
Low grey level count emphasis	TL9H	0.0155	0.0154	0.0007	✅ PASS
High grey level count emphasis	OAE7	501	502	8	✅ PASS
Low dependence low grey level emphasis	EQ3F	0.00387	0.00388	4e-5	✅ PASS
Low dependence high grey level emphasis	JA6D	36.7	36.7	0.5	✅ PASS
High dependence low grey level emphasis	NBZI	0.462	0.457	0.031	✅ PASS
High dependence high grey level emphasis	9QMG	7.6e+04	7.6e4	600	✅ PASS
Grey level non-uniformity	FP8K	8168	8.17e3	130	✅ PASS
Normalised grey level non-uniformity	5SPA	0.184	0.184	0.001	✅ PASS
Dependence count non-uniformity	Z87G	2247	2.25e3	30	✅ PASS
Normalised dependence count non-uniformity	OKJI	0.0505	0.0505	0.0003	✅ PASS
Dependence count percentage	6XV8	1	1	—	✅ PASS
Grey level variance	1PFV	30.5	30.4	0.8	✅ PASS
Dependence count variance	DNX2	39.4	39.4	1	✅ PASS
Dependence count entropy	FCBV	7.06	7.06	0.02	✅ PASS
Dependence count energy	CAS9	0.0106	0.0106	0.0001	✅ PASS

Comprehensive IBSI Benchmark Results

How to Run the Benchmarks

1. Download the Data

2. Run Configurations Programmatically using RadiomicsPipeline

Digital Phantom

Morphology

Intensity

Intensity Histogram

Intensity-Volume Histogram

GLCM

GLRLM

GLSZM

GLDZM

NGTDM

NGLDM

Config C

Morphology

Intensity

Intensity Histogram

Intensity-Volume Histogram

GLCM

GLRLM

GLSZM

GLDZM

NGTDM

NGLDM

Config D

Morphology

Intensity

Intensity Histogram

Intensity-Volume Histogram

GLCM

GLRLM

GLSZM

GLDZM

NGTDM

NGLDM

Config E

Morphology

Intensity

Intensity Histogram

Intensity-Volume Histogram

GLCM

GLRLM

GLSZM

GLDZM

NGTDM

NGLDM

2. Run Configurations Programmatically using `RadiomicsPipeline`